7:45 am Morning Coffee & Check In
8:30 am Chair’s Opening Remarks
Capitalizing & Staying Ahead of the Peptide Revolution
8:45 am Panel Discussion: Uncovering Innovations in Peptide Drug Delivery & Formulation for Improved Bioavailability
Synopsis
• Leveraging ligand-targeted drug delivery in diabetes, oncology and cardiovascular indications
• Enhancing permeability through nanoscale drug carriers, ingestible injectables and more
• Exploring recent innovations in oral peptide delivery for improved bioavailability
9:15 am Diving Into Why We Need to Explore Different Peptide Drug Delivery Options
Synopsis
- Analysis of peptide drug delivery trends and patient needs
- Misconceptions/challenges around subcutaneous delivery and advancement in rapid high volume drug delivery
- Review of the success of oral semaglutide; its impact on patient experience and cost of goods
9:45 am Journey of Challenges: Where Are Peptides Metabolized & How Can We Stop This?
Synopsis
• Identifying the key places where the peptide API gets metabolized, including the stomach, GI tract and liver
• Analyzing the impact of enzymes, pH, and microflora in the metabolism process
• Addressing inherent limitations of certain APIs, such as frequency or conditions of oral administration
10:15 am Morning Break & Speed Networking
Pioneering Devices to Increase the Reach of Peptide APIs
11:15 am Robotic Approaches to Delivering Biologics Orally
Synopsis
- Details to be announced
11:45 am Session Reserved for Pace Analytical
12:15 pm Employing Ingestible Injectables to Circumvent the Challenges of Oral Delivery
Synopsis
• Understanding how ingestible injectables bypass common bioavailability challenges
• Ensuring device compatibility and reliable release during formulation
• Discussing the reach of novel approaches including microneedles
12:45 pm Networking Lunch
1:45 pm Investigating How Tissue Level Targeting Affects Biodistribution of Ingestible Injectables
Synopsis
• Biodistribution pathways when administering to the stomach rather than subcutaneous
• Biodistribution over tissue layers
• LUMI device system for insulin delivery
2:15 pm Empowering Peptide Self-Administration With Needle Free Smart Capsules
Synopsis
• Explaining the mechanism of liquid jet delivery to the small intestine, enabling systemic uptake
• Investigating the device compatibility with various APIs
• Utilizing pH dependent entric coating for precise delivery and why dissolution in a catastrophic fashion is most advantageous
2:45 pm Afternoon Break & Networking
Leveraging Peptide Chemistry to Enhance Bioavailability & Stability
3:15 pm Designing Inherently Bioavailable Peptides With a Combinatorial Screening Approach
Synopsis
• Combining sequential cyclization and one-pot peptide acylation to create diverse cyclic peptide libraries
• Screening cyclic peptides against disease targets, such as thrombin, allowing for multiple iterative cycles of library synthesis
• Creating cyclic peptides with nanomolar affinities, ensuring high stability and demonstrating oral bioavailability
3:45 pm Enhancing Oral Bioavailability of Peptides by Integrated Approaches
Synopsis
• Details to be announced
4:15 pm Utilizing Cyclic & Macrocyclic APIs to Increase Stability: A Review of the Learnings
Synopsis
• Understanding the increased stability of cyclic peptides
• Creating a lipophilic outer layer and hydrophilic inner layer with peptide mimetics
• Innovating with synthetic peptides and unnatural amino acid